Adequan for dogs

Adequan Killed My Dog

Owning a dog is one of the most fulfilling experiences and connections you’ll ever experience. One of the greatest tragedies, though, is witnessing our best friends wither, grow old and start developing joint pains. Your dog is always by your side. So, if your dog develops arthritic discomfort, you want to be able to be there for him or her as well. Luckily, there are injectable able drugs like Adequan that can decrease the progression of osteoarthritis. It also aids in the relief of joint pain and other arthritis symptoms. In this article, we will discuss more on Adequan use, its side effects, how it works, and more

What Is Adequan For Dogs: 

Adequan® is an injectable drug used to treat arthritis in pets. It restores joint lubrication, relieves inflammation, and rebuilds healthy cartilage. Adequan® is most effective when used proactively to keep arthritis from intensifying.  

Why is Adequan® Canine classified as a Disease-Modifying Osteoarthritis Drug or DMOAD?

Unlike medications developed to treat the symptoms of osteoarthritis (OA), a disease-modifying osteoarthritis drug, or “DMOAD,” is a medication capable of altering or slowing the course of OA. Adequan® Canine is a DMOAD since it has been clinically proven to alter the illness as well as treat the symptoms of OA.

The only DMOAD approved by the FDA is Adequan® Canine (polysulfated glycosaminoglycan). It has been shown to be safe and effective in restoring joint lubrication and regenerating the building blocks of healthy cartilage; hence, it is most beneficial when administered early in the OA disease process, when there is still time to slow the clock on cartilage degeneration.

How does Adequan work?

Adequan promotes general joint health. It works by protecting cartilage, a soft, flexible type of connective tissue that cushions the ends of bones. Cartilage acts as a shock absorber. It is smooth, which allows the bone ends to glide over one another. Synovial fluid is present in joint gaps to help minimize friction when joints flex. It is essential in helping to lubricate the joints.

Adequan can help protect the joints and cartilage in a variety of ways. Among them are the following:

Increasing hyaluronic acid (HA) concentration in synovial fluid. This chemical is responsible for synovial fluid’s viscous, lubricating characteristic.

Inhibiting enzymes that degrade cartilage and connective tissue.

Blocking the creation of prostaglandin E2 (PGE2), a naturally occurring hormone that promotes the loss of molecules that make up cartilage and may be linked to a dog’s lameness or pain.

Stimulating the creation of HA, collagen, and proteoglycans, which are necessary for the formation of healthy cartilage.

Lowering protein levels in synovial fluid, which would otherwise lead to inflammation.

Adequan Killed My Dog

Adequan is approved by FDA like many other drugs before being taken to the market. Therefore Adequan cannot kill a dog. However, there are some factors that can lead to death of a dog after taking Adequan like overdosing, allergic reaction or underlying health condition

Is Adequan safe for dogs?

Adequan is a topical anesthetic that relieves pain and inflammation. It has been approved for use in horses, cattle, and dogs by the United States Food and Drug Administration (FDA). Adequate amounts of Adequan are safe and effective when delivered topically to horses, cattle, and dogs during surgery or other medical procedures, according to clinical trials published in The Veterinary Journal and Equine Veterinary Journal.


What is the effectiveness evidence for Adequan® Canine?

Two studies radiolabeled and clinical field trials, demonstrated the efficacy of Adequan canine.

The distribution of radiolabeled PSGAG into canine serum, synovial fluid, and articular cartilage following a single intramuscular (IM) injection of 2 mg/lb body weight was studied. Hips, stifles, shoulders, hocks, and elbows were among the joints examined. The considerable decrease in synovial fluid protein in the shoulder indicates the drug’s effectiveness. 

Field trial: Dogs (n = 51) with radiographically evident degenerative joint degeneration in one or two limbs received IM injections twice weekly for four weeks (total of eight injections). When compared to placebo-treated control dogs, dogs treated with Adequan® Canine demonstrated statistically significant improvements in range of motion and orthopedic ratings.

Precautions Before Using Adequan

Once you have taken your dog with arthritis to your vet, Adequan will not be administered to your dog immediately. Similar to many other types of treatment for different ailments, some dogs may gain from a particular type of treatment, while others may worsen and experience more severe or new problems as a result of the treatment. Here are a few of the most fundamental things a professional should look for before administering any Adequan doses to your dog;

Bleeding Disorders

Adequan should never be given to your dog if the vet suspects hypersensitive to PSGAG (the active ingredient) or if they have any kind of bleeding condition.

Renal Or Hepatic Impairment

Your dog might not be a perfect fit for Adequan if they have ever experienced renal or liver failure. It is a little riskier, even though there are instances where dogs who meet those conditions were able to obtain successful treatments.

Pregnancy, Lactation, Or Breeding

Pregnant or breeding dogs, like humans, should avoid Adequan treatment to ensure that the babies keep growing well. Although dogs in this category are often too young to develop difficulties such as arthritis, you should avoid using Adequan in dogs who are pregnant or are in the process of becoming pregnant.

How often do you give Adequan injections to dogs?

Dogs are given Adequan twice a week for four weeks. To guarantee that the medicine reaches the important portions of the joint, it is administered intramuscularly. It reaches in the joint in around two hours and remains there for about three days.

Once your dog is affected, arthritis will gradually rob him of his carefree life. Arthritis is incurable and it makes your dog’s life difficult because of the continuous muscle deterioration. All you can do now is slow the progress of the illness and make your pet’s life more comfortable.

How long does Adequan take to work?

Adequan will begin to function within 30 minutes following injection. It takes two hours to reach all damaged joints. For three days, the drug lingers in your dog’s cartilage and synovial fluid.

Possible Side Effects of Adequan®

Here are some of the most serious adverse effects that have been reported.

  • Pain, swelling, or hematoma (a blood blister or deep bruise) at the injection site, which could be caused by an infection
  • Anorexia
  • Depression
  • Lethargy
  • Reduced blood clotting, which can result in nosebleeds, gastrointestinal bleeding (bloody, dark coffee ground stool), or vomiting.
  • In rare cases death

Is Adequan safe for long-term use?

Although Adequan is a safe and effective medication for high blood pressure, there are some concerns about long-term use. According to certain research, Adequan can raise the risk of heart issues, stroke, and death. However, there is little information to say whether or not long-term Adequan use is detrimental. If you are prescribed Adequan, you must discuss the dangers and benefits of long-term use with your vet.

When Is The Optimal Time In The Disease Cycle To Use Adequan® Canine?

Early treatment with Adequan® Canine for osteoarthritis is advisable to delay the disease’s progression before irreversible cartilage loss occurs Adequan® Canine has proved to be helpful for people with OA at all phases of the disease cycle, but as mentioned above, it might be most useful at this stage.

Adequan® Storage

Adequan® should be stored at temperatures ranging from 68 to 77°F. Temperatures ranging from 59°F to 86°F are suitable for brief exposure. Avoid prolonged contact with temperatures above 104°F. Use within 28 days of the initial puncture. A maximum of ten uses per vial is advised. All federal, state, and municipal environmental rules must be followed while disposing of discarded needles.  


Is Adequan® Canine a supplement?

No. Adequan® Canine (polysulfated glycosaminoglycan) is a pharmaceutical product approved by the FDA. It has been shown to treat the illness rather than merely the clinical indications of canine osteoarthritis. Many supplements and over-the-counter medicines make claims similar to Adequan Canine. Because these products are not regulated by the FDA, they rely only on unsubstantiated claims and are not subjected to the product testing and clinical trials that Adequan® Canine underwent.

Does Adequan help with hip dysplasia?

Despite not being a cure, Adequan has been demonstrated to have certain advantages in the treatment of hip dysplasia. Adequan works by lowering pain and inflammation to increase mobility and restore joint space. Additionally, it can aid in stopping additional harm to the hip joint. Although some adverse effects are possible when using Adequan, they typically fade away as the medication is stopped.

Does Adequan® affect the liver?

Adequan® side effects can occur if an overdose is given to a pet or if the pet has a known liver condition. Its impact on the liver in healthy pets is typically regarded as safe.

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