Is Simparica Trio Safe For Dogs

Is Simparica Trio Safe For Dogs

Simparica is used to treat flea and tick infestations in dogs. This monthly chewable protect your pet for up to 35 days. Many paw parents like it since it provides a one-stop solution treatment rather than purchasing separate medications for different parasites.

If you’re considering using Simparica to protect your dog against fleas and ticks, continue scrolling to learn more about its safety, dosage, efficacy, side effects, and alternatives.

What is Simparica Trio

Simparica Trio, manufactured by Zoetis, is an improved version of the renowned Simparica chewable oral treatment. It can protect dogs from severe flea and tick infestations. The tasty chewable medicine, which has a liver flavor, kills fleas within four hours after intake and stops existing fleas from reproducing. Simparica Trio eliminates five varieties of ticks, including deer ticks, gulf coast ticks, American dog ticks, and Lone star ticks. Additionally, it helps to completely eradicate adult hookworms and roundworms while also serving as an excellent heartworm preventative. It is only recommended for puppies and dogs older than 8 weeks. You cannot purchase it over the counter; you must get a prescription from your veterinarian.

What Are The Active Ingredients In Simparica Trio And How It Works

There are three active ingredients in Sipomarica Trio; sarolaner, moxidectin, and pyrantel.


Sarolaner belongs to the isoxazoline class of medicines and is an acaricide (kills ticks and mites) and insecticide (kills fleas). It kills fleas, as well as some ticks and mites, by causing uncontrolled neuromuscular activity. Sarolaner is effective against the ticks listed below:

Gulf Coast tick

Brown dog tick

Deer tick/black-legged tick 

American dog tick

Lone Star tick


Moxidectin is a macrocyclic lactone antiparasitic medication. It destroys heartworm larvae by producing paralysis, which results in the parasite’s death.

Pyrantel pamoate

Pyrantel pamoate is a tetrahydropyrimidine-based nematocide (it kills some worms). It paralyzes hookworms and roundworms, causing them to die.

Is Simparica Trio safe for my dog?

“Is it safe for my dog?” is the most critical inquiry concerning any chewable tablet. Although parasite prevention is crucial, it may be worthwhile to consider alternative forms of protection if the risks outweigh the benefits. Some dog owners like the advanced technology of chewable preventatives. Still, it makes no sense to administer Simparica Trio to dogs if it is not safe.

Simparica Trio is considered safe for dogs weighing at least 2.8 pounds and not less than eight weeks old. However, Simparica Trio has not been tested on breeding, pregnant, or lactating dogs.

Before beginning Simparica Trio (or any other heartworm prevention), your dog should be screened for heartworm disease because it does not kill adult heartworms and can actually aggravate your dog’s condition. Simparica Trio may still be used to treat heartworm-positive dogs, but only under the close supervision of a veterinarian.

Simparica Trio should be used with caution in dogs that have had seizures in the past. This is because medications in the isoxazoline class have been linked to neurologic symptoms such as seizures, tremors, and ataxia in dogs with or without a history of neurologic diseases.


In an Australian study conducted in 2017, dogs were given a single monthly dose of sarolaner (Simparica) orally at 2 to 4 mg/kg for three months. It was discovered that the drug was well tolerated by dogs and had high efficacy against flea infestations that occurred naturally under a variety of circumstances. Additionally, it offers 100 percent effectiveness against Haemaphysalis longicornis (Asian longhorn tick) nymphs. Simparica is a safe and reliable remedy for treating and preventing flea infestations.

Here are some of the most crucial details regarding this medication’s efficacy;

Fleas: 100% effectiveness within 24 hours against adult fleas

Heartworm: 100% protection against contracting the disease

Ticks: Ticks are killed within eight hours. Effective against new infections by 94.7%

Roundworms and hookworms: 99.2% effective within 10 days

These are remarkable results, and few medications can boost with such high levels. This is the best a dog owner can do in terms of prevention.

What Is The Difference Between Simparica Trio And Simparica?

Simparica Trio provides triple defense against fatal heartworm, intestinal worms, fleas, and ticks. The best option if you want comprehensive defense in a manageable monthly dose.

Simparica is a treatment that quickly kills fleas, ticks, mange, and mites. The best option is if your dog has a severe flea infestation.

How Should I Administer This Medicine?

Simparica for dogs can be taken orally. This medication comes as a chewable tablet. Reviews of Simparica indicate that the majority of dogs find this to be quite delicious and have no trouble eating it. If your dog is a picky eater, you can disguise this tablet in some boiled chicken or other high-quality treats to ensure that it consumes the entire dose.

Common Side Effects of Simparica Trio

Gastrointestinal Issues: After using Simparica Trio, some dogs may develop diarrhea, vomiting, or a decrease in appetite. The majority of the time, these side effects are minor and go away on their own in a few days.

Lethargy: After taking Simparica Trio, some dogs may experience brief drowsiness or lethargy. The majority of the time, this adverse reaction is brief and passes in a day or two.

Dogs may rarely suffer from more severe adverse effects. These consist of:

Neurological Issues- Simparica Trio has been linked to tremors, ataxia (loss of coordination), and seizures. Despite the rarity of these side effects, it’s critical to keep an eye out for any indications of neurological problems in your dog and to get prompt medical advice if you have any worries.

Skin Reactions: After taking Simparica Trio, some dogs may experience skin problems like itching, redness, or hives. Contact your veterinarian for guidance if your dog displays any of these symptoms.

Liver Issues: Although exceedingly unusual, dogs using Simparica Trio have reportedly experienced liver problems. Signs of liver problems include Jaundice (yellowing of the skin, eyes, or gums), black urine, or light-colored feces. If you detect any of these symptoms, get in touch with your veterinarian immediately.

My Dog Is Allergic to Protein. Does Simaprica for Dogs Contain Any Protein or Other Allergens?

Simparica for dogs has protein, however, it comes in the form of hydrolyzed soy protein. This indicates that even dogs who have a protein allergy are mostly safe. Additionally, this medication contains gelatine, corn syrup, anhydrous dibasic calcium phosphate, corn starch, and wheat germ. 

Simparica Trio Dosage

Simparica Trio should be administered orally once a month at the minimum doses advised: 2.27 milligrams of pyrantel, 0.54 milligrams of sarolaner, and 0.011 milligrams of moxidectin per pound of body weight. It is offered for dogs in six sizes based on body weight range to make dosing simple:

Gold: 2.8–5.5 pounds

Purple: 5.6–11 pounds

Caramel: 11.1–22 pounds

Blue: 22.1–44 pounds

Green: 44.1–88 pounds

Brown: 88.1–132 pounds

Dogs can receive Simparica Trio with or without food.

What should I do if I miss a dose of Simparica Trio?

Simparica Trio should be taken as soon as you remember if a dose is missed. Skip the missed dose if the next one is almost due, and carry on with your dog’s regular dosing plan after that. Never administer two doses to make up for a missed one. Ask your veterinarian for advice if you’re not certain what to do.

Alternatives to Simparica Trio


Bravecto is one well-known substitute for Simparica Trio. The prolonged duration of protection offered by this product makes it a favorite among many dog owners. Bravecto offers up to 12 weeks of protection, while the majority of oral flea and tick treatments require a monthly application. It is a great option for people looking for a more flexible schedule. You must use a heartworm preventative like Heartgard in addition to Bravecto because it does not protect against heartworms.


Another popular option for dog owners looking to protect their animals from fleas and ticks is Nexgard. It’s an appealing, chewable tablet like Simparica Trio that most dogs willingly eat. Contrary to Simparica Trio, Nexgard requires the addition of a different heartworm preventative, like Heartgard or Interceptor. However, Nexgard is a good option due to its simple administration and consistent performance.


Even if your puppy is just four weeks old or two pounds in weight, Capstar can be a great choice. It takes effect just thirty minutes after ingestion. Additionally, it can be safely administered to pregnant dogs as well.

To administer Capstar, no prescription is required. You must keep in mind, though, that this is simply a temporary fix for your parasite issue. It only acts against fleas and lasts for 24 hours.

As a result, if you intend to use Capstar, you should supplement it with other drugs that can help prevent your pet from getting parasites in the long run.


Credelio can be a perfect substitute for Simparica Trio because it has an effective rate of 100%. It takes about 48 hours to start working, which is a longer time than other choices.

However, compared to other choices, the 100% administration success rate elevates it to the top of the list of parasite treatments. A month’s worth of protection is provided by each chewable.

Be cautious when giving Credelio to your dog if he has a history of seizures or neurological issues.

Advantage Multi

Advantage Multi is a topical treatment that provides all-around defense against several parasites. In addition to killing adult fleas and treating flea infestations, it successfully prevents heartworm disease. Furthermore, it manages and treats whipworms, roundworms, and hookworms. Tick protection is not covered by Advantage Multi, thus extra precautions would be required in regions with a high tick population.

Drug interactions

Simparica for dogs is not known to interact with any other medications. However, ask your veterinarian for assistance if your dog is under any other medication or supplements.

What should I do if my dog reacts to a preventative?

Contact your veterinarian immediately if you feel your dog is reacting to a preventive, as indicated by vomiting, extreme itching, lethargy, or behavioral changes. You will be provided with advice on what to do next, which can involve stopping the use of the product and dealing with the reaction.

How do I choose the right preventative for my dog?

It’s important to take into account your dog’s size, age, health, lifestyle, and the kinds of parasites that are prevalent in your area when selecting the best prophylactic. Based on these considerations, consulting your veterinarian can assist you in making the best decision.

How soon can I expect to see results after starting my dog on Simparica Trio?

Within three hours of administration, Simparica Trio begins to kill fleas, and eight hours later, ticks. To maintain continued protection against fleas, ticks, and heartworms, you must continue administering the medication as prescribed by your veterinarian.

Is Simparica Trio Or Simparica Safe To Use For Any Breed Of Dog?

Yes. When administered as indicated, Simparica Trio and Simparica are well tolerated in a variety of dog breeds, even in those with multidrug-resistant protein deficiencies.

Also read: Temaril-P For Dogs

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